Building on the discovery of novel biological mechanisms, Kokuma drives the science-based development of groundbreaking active ingredients.
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Two innovative ingredients offering new horizons for cosmetic brands
The depigmentation market has traditionally relied on tyrosinase inhibitors, which often fall short in delivering optimal efficacy and exhibit concerns regarding their safety profile.
Our innovative ingredient offers a natural alternative with a unique mechanism of action, delivering safe and effective results.
By incorporating Tonasulike-D, our clients, brands and formulators, can create solutions that deliver enhanced efficacy and trusted results for consumers' skin concerns. Setting new beauty standards.
Results in a more uniform skin tone and healthier appearance by reducing unevenness.
Lightens the appearance of age and pigmented spots, ensuring a smooth, consistent skin tone.
Achieves a brighter, glowing skin tone while respecting the skin's natural physiology.
Effective inhibition of melanogenesis by 86% in-vitro on melanocytes, demonstrating the potential to suppress the melanogenesis process and reduce melanin content in the skin.
Human skin explants treated with our ingredient exhibited a 2.4-fold decrease in tyrosinase expression, the enzyme responsible for melanin production, even when exposed to UV light.
Under UV exposure, human skin explants not treated with our ingredient produced 83% more melanin compared to those that were treated.
TONASULIKE-P is a clinically proven breakthrough active ingredient that has the potential to help cosmetic brands to revolutionize their formulations and open new horizons for tone enhancement
A new clinically validated ingredient balancing skin pigmentation by enhancing melanin synthesis.
Demonstrated a twofold increase in skin explants melanin content in a sunless environment compared to UV exposed explants.
The TONASULIKE-P is well tolerated by human skin.
It shows a good pigmentation activity by inducing a significant increase of melanin content and tyrosinase positive cells after 10 days of treatment in a dose dependant manner.
Regarding the induction of melanin, the higher tested concentrations shows better activity.
Kokuma is developing a robust pipeline with two lead programs.
Our mission is to bring breakthrough technologies back to the cosmetic industry by leveraging our deep understanding of AI based research, skin cell biology and melanin synthesis. Through our innovations, we empower individuals to choose their desired skin tone, naturally, using unique physiological pathways.
In 2022, after many years in the biotech industry, our founders' deep knowledge of skin cell biology and melanin synthesis sparked an idea. They decided to revolutionize the beauty industry by finding new, effective ingredients that could naturally influence melanin production.
After countless hours of innovative research and experimentation using advanced technologies like AI, our hard work paid off. We discovered several unique active ingredients that can naturally enhance or reduce melanin production. These discoveries are a game-changer, offering new possibilities in cosmetics and dermatology.
Today, we are working hard to bring our patented innovations to the market. Our goal is to set new standards in skincare and beauty.
C-Level Executive, Board Member,
Senior Advisor
Pharm.D., M.S., ESCP Business School
Key Expertise
Previous Company
Entrepreneur, Venture Capital Investor, Board Member, CFO
Pharm.D., M.Sc., HEC Paris
Key Expertise
Previous Company
Biochemist,
CSO, R&D Director
Ph.D. in Chemistry, University of Rouen
Key Expertise
Previous Company
We prioritize the use of ingredients inspired by nature and physiological processes catering to consumers interested in holistic wellbeing.
Our products are backed by scientific research ensuring efficacy through physiological pathways. AI-driven ingredient selection through predictive testing and data modeling to select the best active ingredient among thousands of candidates.
We approach innovation with care and quality, ensuring every step from creation to consumer delivery is deliberate and considerate.
